Two sample MR report
GBP3_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | -0.0278211 | 0.0236384 | 0.2530345 |
| Weighted median | 22 | -0.0141888 | 0.0039682 | 0.0003495 |
| Inverse variance weighted | 22 | -0.0110738 | 0.0031504 | 0.0004396 |
| Simple mode | 22 | -0.0155457 | 0.0072828 | 0.0447425 |
| Weighted mode | 22 | -0.0162376 | 0.0070898 | 0.0324556 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.510673 | 20 | 0.9762023 |
| Inverse variance weighted | 10.021694 | 21 | 0.9786288 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0144404 | 0.0202004 | 0.4829589 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003818 | 0 | TRUE | 0.0632669 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
